Proteases and the complement system by introduction of unnatural functionality into We focus on diminishing interactions with Introduction, lifetime and immunogenicity. However, protein-based drugs are faced with their own set of limitations, particularly Industry, this has been exacerbated by recent specificity issues with more traditionalĭrugs.

Protein pharmaceuticals represent a rapidly expanding section of the pharmaceutical Have been hindered by the inability to sufficiently control surface interactions. Many of the basic scienceĪnd therapeutic applications, such as gene therapy, oncolytic viruses, and live vaccines, Viruses, which has been limited by solely genetic approaches. Within metabolic engineering is to use this technique to remodel the surfaces of eukaryotic Tracking, dynamics studies, and subsequent chemical modification. Oligosaccharides and DNA with inherent unnatural functionality that can be used for This results in the production of proteins, Metabolic engineering, in the context of our work, involves the introduction of unnaturalįunctionality into biosynthetic processes. Methodologies that we rely upon include organic synthesis, biochemistry and molecular

Oligonucleotides) for the purpose of tracking or perturbing biological processes. We introduce unnatural monomers into the biopolymers of life (proteins, oligosaccharides, The research in our group centers around the concept of chemical biology. California Institute of Technology, 2003 NIH Postdoctoral Fellowship, University of California, Berkeley, 2003-2006ĥ33 Chemistry Phone: (631) 632-7935 Carrico Group Website Chemical Biology, Bioorganic Chemistry and Protein Engineering University of California, Santa Barbara, 1997 Ph.D.

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